This project aims to advance therapeutic drug monitoring for methotrexate in pediatric oncology patients. We introduce a novel, rapid, and cost-effective platform that integrates Surface-Enhanced Raman Scattering (SERS) with centrifugal microfluidics to simplify methotrexate concentration measurements. This automated approach will enable bedside monitoring of patients by non-specialized personnel, improving accessibility and efficiency in patient care.

Funding: Børnecancerfonden

We develop cellulose microparticles for drug delivery to the colon after oral administration.

Funded by DTU Alliance scholarship and Danish National Research Foundation

In collaboration with: Anran Mao and Anna Hanner, KTH Stockholm and Anton A. A. Autzen, DTU Health Tech

We grow cells on a centrifugal microfluidics platform. With a simple disc (same size as a DVD disc) we can grow cells in flow – and without the need for pumps and tubings. 

Funding: NNF Distinguished Innovator, Distinguished Innovator Grant - Novo Nordisk Fonden

We develop and characterize multilayered patches for buccal delivery of GLP-1

Funded by: Horizon Europe

In collaboration with: This project is a Horizon Europe funded project called ‘Buccal-Pep’ (https://buccal-pep.eu/) and coordinated by Prof. David Brayden, UCD Dublin.

The projects performed at DTU Health Tech are in collaboration with: Leticia Hosta-Rigau, DTU Health Tech, Stephan Sylvest Keller, DTU Nanolab and Jette Jacobsen at University of Copenhagen

How can we harvest or transform energy in the gut to fuel ingestible devices for drug delivery, sampling and sensing?

Funding: NNF Challenge grant, Challenge Programme - Novo Nordisk Fonden

Oral drug delivery using self-unfolding devices to increase retention in the gut and proximity to the intestinal lining. We work with e.g insulin and vaccine delivery.

Funding: ERC Advanced grant, Apply for a grant | ERC (europa.eu)

Detection of bacteria in wounds using Raman-based technology

Funding: NNF Pioneer innovator program, Pioneer Innovator Grant - Novo Nordisk Fonden

PI Olesksii Ilchencko 

Development of various types of microneedles for drug delivery to the skin and to the buccal administration site.

New Raman based imaging system to be able to achieve super resolution.

Funding: NNF project in natural and technical sciences, Project Grants in the Natural and Technical Sciences 2023 - Novo Nordisk Fonden

PI Olesksii Ilchencko 

Collaborative European project on detection of chemical threats using Surface Enhanced Raman Scattering (SERS).

 Funding: EU, Home - SERSing

PI Tomas Rindzevicius

Here, we develop nasal sprays incorporating antibiotics and these form gels when introduced into the sinuses and thereby, combating bacterial biofilms locally in the sinuses. 

Funded by: Independent Research Fund Denmark – a Sapere Aude grant

In collaboration with: Prof. Lars Jelsbak,  DTU Bioengineering; Claus Ernst Moser, Copenhagen University Hospitals/University of Copenhagen; Regina Scherließ, Kiel University; Fatemeh Ajalloueian, DTU Health Tech

We investigate particulated platforms as delivery systems for oral administration of vaccines.

In collaboration with: Signe Tandrup Schmidt and Gabriel Kristian Pedersen, SSI and Holger Grohganz, University of Copenhagen

This project aims to advance therapeutic drug monitoring for methotrexate in pediatric oncology patients. We introduce a novel, rapid, and cost-effective platform that integrates Surface-Enhanced Raman Scattering (SERS) with centrifugal microfluidics to simplify methotrexate concentration measurements. This automated approach will enable bedside monitoring of patients by non-specialized personnel, improving accessibility and efficiency in patient care.

Funding: Børnecancerfonden